The principal cytochrome P450 isoenzyme concerned seems to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Around 85% of an oral dose appears while in the urine within 24 hours of administration, most since the glucuronide conjugate, with small quantities of other conjugates and unchanged drug.Adds some sedation, but not an incredible offer. I